When a sinister substitute teacher takes over their class, it is up to Eugene and the rest of the Sunnyview Superhero Squad to find Ms. Beasley and foil the sub's plot.

"Cat is not so keen on stepping in as substitute teacher at Kitty School, but he's surprised by how much he's able to teach the kittens--and how much he learns from them"--

A.J. and his friends are afraid that Ms.Todd, their substitute teacher, has killed their regular teacher and is trying to take over her job.

There is an elegant substitute teacher in class today, but Katie's attempts to impress her keep going wrong.

Sam, Lucy, and Antonio have a new substitute teacher, who happens to be the great-great-grandson of Orson Eerie, the evil scientist whose spirit possesses and infects their elementary school--and the friends are afraid he may be trying to bring Orson back to life.

Seemingly reformed ex-con Zequi is about to marry the love of his life -- the lovably nerdy Lucy -- but wedding-day jitters turn into a full-blown fiasco, and Lucy calls the wedding off. Once they're all seaside, Lucy runs into her high school sweetheart Mario, who is the coach of the opposing squad, and Zequi finds himself a rival in more than one competition.

After learning about Sherlock Holmes, Humphrey the classroom hamster follows clues to try to discover why Mrs. Brisbane is gone and Mr. E, a fun but not very educational substitute, is taking her place in Room 26 at Longfellow School.

When Lee and his vampire friends get a monster for a substitute teacher, they investigate why she is not as nice as she was when she taught at the werewolf primary school their friend Ollie attends.