Two cats that are as different as night and day are nevertheless best friends.

Mallory enters fourth grade with high hopes for her best year ever, but instead she starts by breaking the teacher's rules and then feels left out when her best friend likes the same boy she does.

While seventh-grader Lindy Sachs is recovering from mononucleosis, her father gives her access to his etrading account as a way to pass the time and she discovers that she has a knack for buying and selling stocks.

While on vacation in California, sixteen-year-old best friends Anna and Frankie conspire to find a boy for Anna's first kiss, but Anna harbors a painful secret that threatens their lighthearted plan and their friendship.

Returning home with the exciting news that she is marrying the love of her life and is pregnant, Frankie struggles to adjust when she learns her father is also getting married to her pregnant best friend.

As she begins her first year of high school, fifteen-year-old Imogene is embarrassed by the blog her mother writes that has included every detail of Imogene's life since she was born.

Best friends Emily and Vicky dress the same and declare themselves twins in spite of their classmates' arguments that they look nothing alike.

Freckleface Strawberry and Windy Pants Patrick are best friends because they have so much in common, but when the boys convince Windy Pants that he should play with them at recess, and the girls convince Freckleface Strawberry to play with them, the friends see that they are very different, too.

Lucy and Soledad have been best friends all their lives--until jealousy causes Soli to wish Lucy away.

Six stories relate the adventures of three best friends, who happen to be toys.